Autism Research Paper by Donald C. Rojas et. al.

Autism Research Paper

by Donald C Rojas et. al.

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Title: Reduced neural synchronization of gamma-band MEG oscillations in first-degree relatives of children with autism (2008).

by Donald C Rojas*¹, Keeran Maharajh¹, Peter Teale¹ and Sally J Rogers²
Address: ¹University of Colorado at Denver and Health Sciences Center, 4200 E. 9th Avenue, Denver, CO, USA ² The M.I.N.D. Institute,University of California at Davis, Sacramento, CA, USA

BMC Psychiatry 2008, 8:66 doi:10.1186/1471-244X-8-66

Published: 1 August 2008
Received: 18 December 2007
Accepted: 1 August 2008

This article is available from: http://www.biomedcentral.com/1471-244X/8/66. (Right-click the link to download and print a PDF file.)
© 2008 Rojas et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract:
Background: Gamma-band oscillations recorded from human electrophysiological recordings, which may be associated with perceptual binding and neuronal connectivity, have been shown to be altered in people with autism. Transient auditory gamma-band responses, however, have not yet been investigated in autism or in the first-degree relatives of persons with the autism.

Methods: We measured transient evoked and induced magnetic gamma-band power and inter-trial phase-locking consistency in the magnetoencephalographic recordings of 16 parents of children with autism, 11 adults with autism and 16 control participants. Source space projection was used to separate left and right hemisphere transient gamma-band measures of power and phase-locking.

Results: Induced gamma-power at 40 Hz was significantly higher in the parent and autism groups than in controls, while evoked gamma-band power was reduced compared to controls. The phase-locking factor, a measure of phase consistency of neuronal responses with external stimuli, was significantly lower in the subjects with autism and the autism parent group, potentially explaining the difference between the evoked and induced power results.

Conclusions: These findings, especially in first degree relatives, suggest that gamma-band phase consistency and changes in induced versus induced power may be potentially useful endophenotypes for autism, particularly given emerging molecular mechanisms concerning the generation of gamma-band signals.

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